Although genome-wide surveys have detected NFKB1 rearrangements in myeloma (e.g. PIM2::NFKB1) (18) and have exhaustively catalogued IGH translocation partners (19), an IGH::NFKB1 fusion has never been reported, supporting the novelty of the alteration described here. The gene discussed is PIM2; the disease is plasma cell myeloma.