HuR in CRC cells stabilizes ARE-containing RNAs and/or promotes their translation, enhancing the production and release of oncogenic factors such as COX-2 (133), tumor necrosis factor-alpha (TNF-α) (134), interleukin-8 (IL-8) (135, 136) and interleukin-6 (IL-6) (137), enhancing their roles in the inflammatory microenvironment, exacerbating the inflammatory response, and promoting CRC cells proliferation and survival (36). Here, PTGS2 is linked to colorectal carcinoma.