miR-224-5p and miR-143-3p, located near the ARE of oncogenes, regulate proto-oncogenes such as HNF4, NOTCH4, and SLC2A4. Along with miR-1-3p, they increase the expression of RBBP4, promoting the proliferation and invasion of CRC cells. Here, NOTCH4 is linked to colorectal carcinoma.