demonstrated that HuR promotes CRC cell proliferation by stabilizing HOXC6 mRNA and enhancing its transcriptional activity, while regulating the molecular network of miR-34b-5p/SNHG3 mediated by CAFs-derived extracellular vesicles (68).We summarize the current research on the mechanisms by which ncRNAs interact with HuR to regulate tumor-related cellular processes in CRC (Table 1) and will subsequently elaborate on the therapeutic applications of miRNA- and lncRNA-mediated HuR targeting. Here, HOXC6 is linked to neoplasm.