AR and posterior cortical atrophy: ADT-induced AR gene transcription rate and recruitment of splicing factors to AR pre-mRNA contribute to enhancing AR-V7 levels in prostate cancer cells, thereby leading to the development of drug resistance (10).But CRPC-like cells are reported that it present early in the development of PCa and are not exclusively the result of acquired evolutionary selection during ADT, which may require aggressive early intervention (11).