Specifically, in GSE185344 dataset, SPON2 has the highest expression in olfactory epithelial cells, AGR2 in ciliated cells, MSMB and TMEFF2 in basal cells, and CLU in schwann cells; in GSE181294 dataset, SPON2, AGR2 and TMEFF2 have the highest expression in tumor cells, MSMB in luminal cells, and CLU in endothelial cells; in GSE17144 dataset, SPON2, AGR2, MSMB and TMEFF2 have the highest expression in epithelial cells, and CLU in endothelial cells. The gene discussed is CLU; the disease is neoplasm.