From an implementation perspective, the 10-gene signature (CLIC1, NAP1L1, CBX3, RAN, APOE, CD63, CLTA, SNRPG, FTL, and POMP) could be assessed using RT-PCR or targeted RNA sequencing, making it feasible for integration into clinical testing workflows alongside established prognostic factors to guide treatment decisions throughout the HCC care continuum. Here, APOE is linked to hepatocellular carcinoma.