RAN and hepatocellular carcinoma: From an implementation perspective, the 10-gene signature (CLIC1, NAP1L1, CBX3, RAN, APOE, CD63, CLTA, SNRPG, FTL, and POMP) could be assessed using RT-PCR or targeted RNA sequencing, making it feasible for integration into clinical testing workflows alongside established prognostic factors to guide treatment decisions throughout the HCC care continuum.