VEGFA and neoplasm: Studies have confirmed that 92.3% of micrometastases with a diameter of< 1 cm rely on hepatic artery blood supply, while TACE can achieve selective killing through local embolization and high concentration of chemotherapeutic drugs (hepatic artery administration concentration is 9 times higher than intravenous administration), so that the clearance rate of microvascular tumor thrombus is increased to 73.6% (LR group 34.2%, p< 0.001) (37); TACE therapy can inhibit the VEGF signal at the peak of postoperative angiogenesis (decreased by 72.3%), and transiently activate anti-tumor immunity.