While leptin has been shown to impact various T cell subsets, including Tregs, it has also been reported to enhance the activity of naïve and memory T cells (55, 56).Interestingly, in the context of oncolytic virus therapy for melanoma, leptin’s overexpression has been associated with increased activation of CD8+ T cells and enhanced mitochondrial biogenesis. The gene discussed is LEP; the disease is melanoma.