To enable targeted trafficking of CAR-T cells into tumors, cells expressing receptors for chemokines specifically produced within the tumor microenvironment (e.g., CXCR2/CXCL1, CCR2b/CCL2, CXCR1 (2)/IL-8(CXCL8), CX3CR1/CX3CL1, CSF-1R/CSF-1) are being engineered. Here, CX3CL1 is linked to neoplasm.