When Balb/c mice were inoculated with mouse IFNγ and an anti-Acr IgA TBA61 mAb via the intranasal route (i.n.), a synergistic protective effect on reducing bacterial burdens can be found for the lungs harvested 3 and 4 weeks after H37Rv aerosol infection, while neither component alone was protective (90, 127) (Table 2). The gene discussed is ACR; the disease is infection.