Notably, five proteins exhibited risk-promoting effects for AML progression (GRAP2 OR = 9.32, 95% CI: 2.28-38.151; TNFAIP8 OR = 3.66, 95% CI: 1.69-7.90; TCL1A OR = 2.34, 95% CI: 1.44-3.78; WFDC1 OR = 1.85, 95% CI: 1.40-2.46; C7 OR = 1.29, 95% CI: 1.10-1.52);, while TNFSF8 showed protective potential (OR = 0.33, 95% CI: 0.17-0.67). Here, GRAP2 is linked to acute myeloid leukemia.