ANXA1 and infection: Our results are consistent with previous work in an endotoxin-induced uveitis model in rodents and in vitro studies with human cells, where systemic and topical administration of ANXA1 resulted in decreased leukocyte infiltration in ocular tissues and reduced expression of inflammatory mediators (15).Similar findings have been reported in another study using a model of L. amazonensis infection demonstrating that the absence of ANXA1 results in greater susceptibility to infection, with exacerbated inflammatory responses, impaired control of parasitism, and reduced IL-10 levels (43).