Building upon a profound understanding of the “prion-like” propagation of pathological proteins in AD and prion diseases (Jucker and Walker, 2018; Peng et al., 2020), the concept of misfolded protein aggregates (e.g., PrPSc, Aβ, and tau) as pathogenic “seeds” has opened novel avenues for diagnosing neurodegenerative disorders (Shi et al., 2021). Here, MAPT is linked to Alzheimer disease.