Different tauopathies (e.g., PSP, CBD) exhibit distinct conformations of tau fibrils (e.g., twisted helical shape in PSP, disordered conformation in CBD), further emphasizing the critical role of conformational heterogeneity in determining disease phenotypes (Aragão Gomes et al., 2021; Tarutani et al., 2023a,b; Zhang et al., 2020). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.