EPHA1 and neoplasm: Eph/ephrin signaling is broadly dysregulated across primary central nervous system tumors, but its functional consequences are highly context- and lineage-dependent, varying with tumor type, molecular subgroup, cellular state and the microenvironment (Liu et al., 2007; Hao et al., 2021; Sikkema et al., 2012; McKinney et al., 2015; Morrison et al., 2013; Bhatia et al., 2015; Gokhale et al., 2010; Kool et al., 2008).