EphB2 is also stabilized under hypoxia by HIF-2α and promotes GBM cell invasion via paxillin phosphorylation, suggesting a HIF-2α-EphB2-paxillin axis that supports epithelial-mesenchymal transition (EMT) and tumor aggressiveness (Qiu et al., 2019). This evidence concerns the gene EPAS1 and neoplasm.