Co-localization of EphB4/ephrin-B2 with CD34 in stromal microvessels and GFAP in tumor cells has been observed, with higher expression levels in poorly differentiated tumors, reinforcing its relevance to both tumor aggressiveness and vascular pathology (Uhl et al., 2018; Xiao et al., 2004). The gene discussed is GFAP; the disease is neoplasm.