EFNB1 and neoplasm: EphB1 is co-expressed with genes such as ephrin-B1, RND1/2, and SEMA3A, key regulators of neuronal migration, synaptogenesis, and axonal development, indicating that neurodevelopmental pathways may be hijacked to support tumor growth (Gokhale et al., 2010; Kool et al., 2008).