Stimulation with ephrin-A1 failed to elicit notable phenotypic effects, whereas ephrin-B1 induced modest activation of type A Eph receptors in Uw-402, suggesting cross-reactivity and ligand promiscuity within the Eph/ephrin system in medulloblastoma (Sikkema et al., 2012). This evidence concerns the gene EFNB1 and medulloblastoma.