Interestingly, a Wnt5a∧High/EphA2∧Low GSC subpopulation was more tumorigenic than Wnt5a∧Low/EphA2∧High cells, and combined inhibition of Wnt5a and EphA2 drastically reduced invasion and tumor growth (Trivieri et al., 2022). The gene discussed is EPHA2; the disease is neoplasm.