Our results indicated that IRSp53 is a substantial aim in colon cancer remedy and secretome of hAMSCs suppresses IRSp53 expression as well as related molecules such as IRSp53, p-AKT (Ser 473), p-Stat3 (Tyr 705), and cyclin D1 in the HT-29 colon cancerous cell line. Here, STAT3 is linked to malignant colon neoplasm.