STAT3 and neoplasm: For evaluating possible impacts of the secretome of the hAMSCs on tumor growth plus progress via EGFR/c-Src/IRSp53/p-AKT/p-Stat3/cyclin D1 signaling pathway, first coculturing of HT-29 colon cancerous cells /hAMSCs was fulfilled for 72 h afterward, they underwent MTT assay (Figure 3B).