Furthermore, in a UTUC patient-derived organoid model, high expression levels of RRBP1 have been associated with chemoresistance to cisplatin, gemcitabine and epirubicin (8); therefore, it synergistically promotes tumor cell survival by modulating ERS and yes-associated protein 1 (YAP1) signaling (Fig. 4) (8). The gene discussed is YAP1; the disease is neoplasm.