FCGR2A and neoplasm: Cross-platform harmonization identified 130 co-dysregulated genes enriched in myeloid immune functions, with FCGR2A emerging as the central hub gene exhibiting robust diagnostic power (AUC=0.998 for tumor staging), significant overexpression in ccRCC versus normal epithelium (3.1-fold, p=0.002), and specific localization to M2 macrophages in single-cell analyses (log2FC=4.6, adj.p=1.3×10−7).