Concurrently, FCGR2A ligation amplifies IL-6 secretion via canonical NF-κB signaling (IL-6+ cell density: 28.3 vs 9.7/cm2, p=0.003), driving STAT3 phosphorylation in ccRCC cells (pSTAT3[Y705]↑3.8-fold) that sustains protumorigenic CCL2/CSF1 paracrine loops (58). This evidence concerns the gene NFKB1 and nonpapillary renal cell carcinoma.