KEGG enrichment identified neutrophil-mediated defense mechanisms as central shared pathways, with Staphylococcus aureus infection (C1QA/B/C, P = 2.2×10-11) and neutrophil extracellular trap formation (ITGAM/ITGB2, P = 7.3×10-10) exhibiting strongest associations (Figures 4A, B) (21). The gene discussed is ITGB2; the disease is staphylococcus aureus infection.