SREBF1 and cystic fibrosis: In detail, genes such as acc, fatty acid desaturases (fad), elovl5, and srebp1 were significantly upregulated in the HL group versus the CF group (p < 0.05), with no significant difference between HL and HL + A groups (p > 0.05), but a significant downregulation in the HL + S group (p < 0.05).