IL6 and neoplasm: In patient-derived brain metastasis samples, analysis of breast cancer brain metastasis samples using 10x Visium and NanoString GeoMx demonstrated geographic variability in immune suppression, characterized by perivascular niches populated by macrophages and tumor cells that express neuroinflammatory genes, including CXCL10 and IL-6 (Kang et al., 2025).