Based on current research findings, the FGD5 protein may regulate vascular pruning by participating in the VEGF (vascular endothelial growth factor) signaling pathway and activating the CDC42 protein, thereby modulating neovascular networks in both physiological conditions and tumor tissues (Farhan et al., 2017; Heldin et al., 2017; Valla et al., 2018). This evidence concerns the gene FGD5 and neoplasm.