SORL1 and obesity due to melanocortin 4 receptor deficiency: When comparing MU females with MU males, the proposed upstream regulators include the increase in sexual hormones (beta-estradiol, estrogen), IL10RA, SORL1, DRD2, L-triiodothyronine and a reduction in COPS5. Overall, the activation network predicts the activation of cellular processes such as inflammatory response and quantity of connective tissue, but a predicted inhibition on lipid-accumulation pathologies such as weight gain and obesity (Fig. 3E).