TFE3, MLANA, HMB45, and CTSK are not sufficiently reliable for distinguishing TFE3‐RCC from KIRC and KIRP.[8, 9] While strong positive nuclear staining of TFE3 in TFE3‐RCC is typically associated with TFE3 fusion protein expression, some KIRC or KIRP cases stain positive for TFE3 because of autophagy activation, leading to potential false‐positive diagnoses. Here, CTSK is linked to renal cell carcinoma.