SV2B, a synaptic vesicle protein 2 (SV2) family member, acts as a redundant Ca2+ regulator in neurotransmitter release.[23, 24] Lack of SV2B protein can disrupt synaptic circuits and lead to epilepsy.[23, 24] Elevated SV2B levels have been associated with poor prognosis in glioblastoma and uterine corpus endometrial cancer.[25, 26] However, its potential as a diagnostic marker for TFE3‐RCC and biological function in tumors, particularly in TFE3‐RCC, remains to be elucidated. This evidence concerns the gene SV2B and renal cell carcinoma.