Taking into consideration that the PMCA3 R482H mutation co-occurs with a compound heterozygous mutation in the LAMA1 gene coding for the laminin subunit 1α (already demonstrated to be linked to cerebellar dysplasia [144]), it is reasonable to suggest that PMCA3 dysfunction may act as a digenic modulator in Ca2+-linked pathologies, thus contributing to, or exacerbating, ataxic symptoms related to LAMA1 mutations [144]. This evidence concerns the gene LAMA1 and Cerebellar dysplasia.