ATP2B2 and cerebellar ataxia: PMCA2 is particularly abundant in the cell bodies, dendrites and dendritic spines of cerebellar PCs [59, 132] where it rapidly clears the Ca2+ inputs received from PFs [59, 132, 133], thus explaining also why both PMCA2-null and deafwaddler 2 J (dfw2J) mice [27, 106, 134] manifest cerebellar pathology, resulting not only in deafness, as previously discussed, but also in motor deficits and ataxia.