Notably, studies in the Cln6 model of Batten disease revealed that male mutant mice accumulate more storage material in the somatosensory cortex and thalamus at 2 months of age, whereas female Cln6 mutant mice surpass males in storage material by 6 months of age in these same regions [44]. Here, CLN6 is linked to juvenile neuronal ceroid lipofuscinosis.