For instance, a t-SNE cluster enriched for KRAS-mutant cases exhibited high expression of both HNF4A and MUC5AC, which are expressed at high levels in invasive mucinous adenocarcinoma, a distinct histological subtype of LADC18 (Fig. 1c and Supplementary Fig. 1e, f). This evidence concerns the gene MUC5AC and colon mucinous adenocarcinoma.