Conversely, in AD, NRP2 was downregulated in astrocytes (protein log2(AD/control) = −0.302, FDR = 0.002) and its ligands SEMA3B and SEMA3C were downregulated in LPS-injected mice (Supplementary Fig. 12 and Supplementary Data 7). This evidence concerns the gene SEMA3C and Alzheimer disease.