In line with sepsis and peripheral infections increasing the risk for stroke35, polymorphisms of WNT10B66 are associated with Korean cerebral infarction; and Fzd7 activation (in a yet-to-be-identified cell type) has been shown to attenuate BBB disruption after stroke via a downstream signaling cascade involving dishevelled and catenin beta-167. This evidence concerns the gene FZD7 and brain infarction.