Numerous reports have revealed that Cu ions have a close relationship with tumor angiogenesis through enhancing the pro-angiogenic factors like angiopoietins (Ang), vascular endothelial growth factor (VEGF), fibroblast growth factors (FGFs), placental growth factor (PLGF), interleukins (IL), and integrins [27]. This evidence concerns the gene VEGFA and neoplasm.