GEPIA showed that high expression of several ER stress markers Is associated with an increased risk of distant metastasis in men with PCa: MYCN: Hazard ratio (HR) for relapse = 2.1, p = 0.0018; DDIT3: HR for relapse = 2.3, p = 0.00019; PDI (Protein Disulfide Isomerase: HR for relapse = 2.0, p = 0.0012 and NOS3: HR for relapse = 1.7, p = 0.015 respectively. The gene discussed is P4HB; the disease is posterior cortical atrophy.