Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed these molecules were primarily involved in the HIF-1 signaling pathway, legionellosis, and glycolysis/gluconeogenesis (Fig. 4E, F), highlighting the concordance between transcriptomic and proteomic profiles. The gene discussed is HIF1A; the disease is legionellosis.