STUB1 and B-cell chronic lymphocytic leukemia: This potential synergistic interaction between MBL and CHIP was supported in stratified analyses in individuals with MBL only and indirectly observed in Niroula et al. [17], in that they found more than a 500-fold elevated risk of CLL in individuals with L-CHIP who had lymphocytosis (a presumed surrogate for HC-MBL).