Recently, the definition of CHIP has expanded to include mutations in 235 genes related to lymphoid malignancies, and individuals with CHIP mutations in these lymphoma-related genes were reported to have a 4.2-fold (95% CI: 2.7–6.7) increased risk of incident lymphoid malignancies and a 20-fold (95% CI: 11.1–38.0) risk for incident CLL, specifically [17]. This evidence concerns the gene STUB1 and lymphoma.