NFE2L2 and diabetes mellitus: Stancic et al. used the rat pancreatic beta cell line Rin-5F to induce cell death via DM mimics, including high glucose, H2O2, and STZ, and reported that these factors accumulate ROS and iron, inactivate NRF2, and reduce the mitochondrial membrane potential, while treatment with Fer-1 mitigated these effects [87].