Pharmacological agents such as fenofibrate, carnosine, umbelliferone, paricalcitol, leonurine, triptolide, DDO-1039, and Potentilla Discolor Bunge(whose main active components are quercetin, kaempferol, and β-sitosterol) can upregulate NRF2, thereby suppressing ferroptosis and decelerating the progression of diabetic nephropathy [118–126]. Here, NFE2L2 is linked to diabetic kidney disease.