Dong et al. demonstrated that ferroptosis, accompanied by decreased FNDC5 expression, occurs in both STZ-induced type 1 diabetic mouse bone tissue and high glucose-exposed MC3T3-E1 cells, with irisin administration or FNDC5 overexpression ameliorating type 1 diabetic bone loss via inhibition of endoplasmic reticulum stress-mediated ferroptosis [177]. The gene discussed is FNDC5; the disease is type 1 diabetes mellitus.