Ferroptosis has been identified in the hippocampus of the HFD/STZ-induced T2DM model, as reported by Xie et al. Research indicates that ferroptosis predominantly occurs in hippocampal neurons rather than in microglia or astrocytes and is characterized by increased transferrin receptors and reduced levels of ferritin, GPX4, and SLC7A11 in these neurons [156–158]. Here, GPX4 is linked to type 2 diabetes mellitus.