Analogous to the assessment of Xkr8 in cell-intrinsic oncogenic features, TMEM16F knockout cells also did not show defects in tumor cell proliferation (Fig. 3E) or tumor-sphere formation in Matrigel, as shown by tumor-sphere size (Fig. 3F) and tumor-sphere count (Fig. 3G), or defects in the immediate Gas6-mediated activation of Akt (Fig. S3B). Here, XKR8 is linked to neoplasm.