XKR8 and neoplasm: Interestingly, in a similar capacity to Xkr8, the TMEM16F KO tumors also showed significant reduction in tumor growth compared to WT tumors (employing 2 independent clones for validation), as evident by the decrease in tumor volume (Fig. 4A, D), tumor weight (Fig. 4B, E) and spleen weight (Fig. 4C), as well as increased overall survival of mice with TMEM16F KO tumors, as indicated by a Kaplan–Meier curve (Fig. 4F).