Although the biochemical mechanisms by which loss of Xkr8 and TMEM16F impinge on tumor growth are still not clear, our results are consistent with a recent study by Chen and colleagues showing that co-delivery of an Xkr8 small interference RNA (siRNA) with platinum chemotherapy (to enhance apoptosis) showed increased therapeutic efficacy in an orthotopic pancreatic tumor model with an increase of proliferative NK cells and activated macrophages infiltration in the tumor microenvironment [61]. Here, ANO6 is linked to neoplasm.