Interestingly, unlike the Xkr8 knockout phenotype, the TMEM16F KO tumors showed a slight reduction in tumor growth in Rag1 KO mice (which lack mature T and B lymphocytes), with modest effects in tumor volume (Fig. 4L) and tumor weight (Fig. 4M), possibly suggesting that tumor reduction due to Xkr8 KO is more dependent on the mature T and B cells, whereas, in the TMEM16F KO tumors, there is a combined effect of the immune system and other factors, possibly, angiogenesis and modulation of the extracellular matrix, driving the reduction in tumor progression. This evidence concerns the gene ANO6 and neoplasm.