Interestingly, unlike the Xkr8 knockout phenotype, the TMEM16F KO tumors showed a slight reduction in tumor growth in Rag1 KO mice (which lack mature T and B lymphocytes), with modest effects in tumor volume (Fig. 4L) and tumor weight (Fig. 4M), possibly suggesting that tumor reduction due to Xkr8 KO is more dependent on the mature T and B cells, whereas, in the TMEM16F KO tumors, there is a combined effect of the immune system and other factors, possibly, angiogenesis and modulation of the extracellular matrix, driving the reduction in tumor progression. The gene discussed is RAG1; the disease is neoplasm.