SRSF11 and hepatocellular carcinoma: This finding assumes clinical significance given that radiation-induced DNA damage, while cytotoxic to malignancies, is counteracted by tumor cells through compensatory upregulation of the repair machinery—a key mediator of radioresistance.10,12,40 HR and NHEJ are the main repair pathways of DNA damage repair.13 Strikingly, IR-challenged HCC models demonstrated that SRSF11 ablation selectively impaired HR pathway activation while sparing NHEJ, establishing HR as the dominant DDR effector of SRSF11 in HCC.