We overexpressed Flag-SRSF11 or Flag-SRSF11 K419R in HCC cells, respectively, and found that the RAD52 pre-mRNAs binding to SRSF11 was dramatically suppressed in overexpressed Flag-SRSF11 K419R cells (Supplementary Fig. 7d). This evidence concerns the gene RAD52 and hepatocellular carcinoma.