First, we found that SRSF11 silencing dramatically augmented DNA damage caused by IR in RAD52-overexpressing HCC cells, as shown by a colony formation assay (Fig. 5a), comet assay (Fig. 5b), γH2AX staining (Supplementary Fig. 6a), and limited HR (Supplementary Fig. 6b). Here, SRSF11 is linked to hepatocellular carcinoma.