NLRP3 and age-related macular degeneration: Overall, our findings on the importance of Nlrp3 in BLamD formation adds to the growing body of research identifying potential therapeutic routes to alleviate or delay pathology in ML/DHRD [57, 58, 75], and support the idea that select retinal dystrophies with phenotypic similarities to AMD can be likely used as proving grounds to develop breakthroughs in etiologically complex, yet prevalent diseases such as sporadic AMD.