In further support of inflammasome involvement in the pathology of AMD, recently a 38 yo Chinese female with a constitutively active, autosomal dominant autoimmune mutation in NLRP3 (c.1043 C > T, p.T348M) presented with pseudodrusen and hard drusen near the optic nerve [46]. The gene discussed is NLRP3; the disease is age-related macular degeneration.