EFEMP1 and glaucoma: Given the recent findings that mutations in EFEMP1 can cause juvenile onset glaucoma [89–91], and that the R345W mutation may predispose some human patients to corneal opacity [92] or even glaucoma itself [93], we tested whether the R345W mutation predisposed mice to corneal changes, elevated intraocular pressure (IOP) or retinal ganglion cell (RGC) death.