Further supporting the notion of role of NLRP3 in pathology resembling AMD, recently a 38 yo Chinese female with an autosomal dominant, autoimmune mutation in NLRP3 (c.1043 C > T, p.T348M) presented with pseudodrusen (amorphous material between the RPE and photoreceptors) and hard drusen near the optic nerve [46]. Here, NLRP3 is linked to age-related macular degeneration.