NLRP3 and age-related macular degeneration: While the NLRP3 inflammasome has not been directly implicated in the pathology of ML/DHRD to date, extensive findings in mice and cultured cells implicate a key role for immune-related complement activation in R345W BLamD pathology [69–72, 76–79], a clinically-observed pathology that likely contributes toward the formation/progression of high-risk drusen in AMD patients [80].