For example, positive correlations between DHCR7 expression and the immune inhibitors CD276 and VEGFA were found in many cancers, such as TGCT, BLCA, HNSC, LUAD, LUSC, STAD, STES, CESC, SARC, and PRAD, etc. For immune activators, negative correlations between DHCR7 expression and CD27, GZMA, CCL5, PRF1, ICOS, CD28, or CD40LG were shown in BLCA, HNSC, LUAD, LUSC, KIRC, STAD, STES, CESC, SARC, KIPAN, and ACC. The gene discussed is ICOS; the disease is bladder transitional cell carcinoma.