Among 60 ICP genes, including 24 immune inhibitors (such as CTLA4, LAG3, or VEGFB) and 36 activators (TNFRSF9, CD28, or TNFRSF9, etc.), we found DHCR7 played roles both in inhibitors and activators of ICP in human cancers (Figure 7). The gene discussed is CTLA4; the disease is cancer.