GPR68 and inflammatory bowel disease: Consistent with reports of a proinflammatory role for GPR68 in colitis,22,25 we showed that GPR68-/- mice exhibited significantly less disease activity following DSS-induced acute colitis, and in silico analysis of our reported RNA sequencing (RNA-seq) data revealed increased expression of GPR68 alongside other proton-sensing GPCRs in colonic biopsies from individuals with IBD.30