To assess whether this observation was consistent in physiological conditions, we analyzed the expression patterns of CypD and Mia40 in isolated mitochondria from 10 different human leukemia cell lines (MOLM-16; KG-1; HL-60; OCI-AML2; OCI-AML3; THP-1; MOLM-14; SKM-1; NOMO-1; HEL). This evidence concerns the gene CHCHD4 and leukemia.