We performed immunostaining of tissue sections at 0 W and 12 W that revealed the increase in senescent cells and the proliferation of HPCs marked by CD133 and CK19 (Figs. 3, G, H and S4, D, E), which further supports the notion that senescent cells can enhance HPC generation, thereby facilitating the occurrence of liver cancer. The gene discussed is PROM1; the disease is liver cancer.