We performed immunostaining of tissue sections at 0 W and 12 W that revealed the increase in senescent cells and the proliferation of HPCs marked by CD133 and CK19 (Figs. 3, G, H and S4, D, E), which further supports the notion that senescent cells can enhance HPC generation, thereby facilitating the occurrence of liver cancer. This evidence concerns the gene KRT19 and liver cancer.