Recruited monocytes are a major source of alveolar macrophages in sarcoidosis.71They exhibit increased expression of P2X7 receptors which enhances their ability to form MGCs, a hallmark of granulomatous inflammation.72These phenotypic and functional shifts position monocytes as pivotal drivers of the persistent antigen presentation and dysregulated inflammation that sustain granuloma formation in sarcoidosis. This evidence concerns the gene P2RX7 and sarcoidosis.