HLA-DRB1 and sarcoidosis: To address this gap, one of the largest multiethnic GWAS to date, conducted by Liao et al, examined genetic risk for sarcoidosis in European American and African American cohorts, and identified HLA alleles DRB1 * 0101, DQA1 * 0101, and DQB1*0501 as shared risk variants across both groups.10These findings reinforce the central role of HLA variation in modulating susceptibility, phenotype, and prognosis, while clarifying both common and ancestry-specific genetic determinants of sarcoidosis.