ITGAX and Granuloma: Using these techniques, Carow et al showed that sarcoidosis granulomas lack the tertiary lymphoid structures and organized antigen-specific niches characteristic of tuberculosis, and are instead composed of myeloid-rich, lymphocyte-poor cores enriched in macrophage-associated transcripts including CD11b (ITGAM), CD11c (ITGAX),CD14, andHLA-DRA.