TNF and sarcoidosis: Monocyte recruitment to inflamed tissue is orchestrated by chemokines, CCL2, CCL7, and CCL20, which are upregulated in response to proinflammatory stimuli, as well as by cytokines such as IFN-γ and TNF-α, both of which are elevated in the granulomatous microenvironment.75, 76Monocytes in sarcoidosis demonstrate enhanced migratory potential, shaped by dynamic regulation of chemokine receptors across compartments.