CD4 and Granuloma: Markedly diminished levels have been observed in circulation and are often absent in mediastinal lymph nodes, granulomas, and cutaneous lesions.157, 158In the lung, reduced iNKT cell frequencies in BALF negatively correlate with CD4+T cell abundance, suggesting a potential role in regulating local T cell expansion.159In contrast, patients with acute, self-limited disease such as Löfgren syndrome often exhibit preserved or increased iNKT cells in BALF, a pattern associated with better prognosis.159, 160