Several non-HLA susceptibility loci have been described, including IL23R, ATXN2/SH2B3, ANXA11, IL12B, and MANBA/NFKB1.11, 12Functional studies and transcriptome-wide association analyses suggest that these genes participate in key immunologic processes relevant to sarcoidosis. The gene discussed is NFKB1; the disease is sarcoidosis.