The lower expression of TNF, NCF2, and DIP2B mediated the adverse effect of the methylation at cg04425624 and cg03037030 (TNF), cg09076123 (NCF2), and cg05512157 (DIP2B) on CRC, respectively, and higher expression of BICC1 mediated the adverse effect of the methylation at 4 CpGs (cg08353444, cg23963517, cg06424110, cg09578524) on CRC. The gene discussed is TNF; the disease is colorectal carcinoma.