PRDM1 and digestive system neoplasm: Since TCR signaling is required for Treg suppressive function24 and a distinct population of highly self-reactive Tregs (Nur77hiCD5hi) with increased TCR signaling losses its suppressive capacity to protect recipients from colon inflammation in adoptive transfer models,25 we examine whether the suppressive discrepancy between Blimp-1-deficient NOD Tregs and B6 Tregs correlates with their TCR signaling strength by RNA-seq and flow cytometry analysis.