A subset of highly self-reactive Tregs with enhanced TCR signaling, characterised by high CD5 and nuclear receptor subfamily 4 group a member 1 (Nur77) expression, loses its ability to prevent colitis in a T-cell transfer model, suggesting an inverse correlation between TCR signaling strength in Tregs and their suppressive function in colitis models.25 This evidence concerns the gene NR4A1 and colitis.