CCR6 and colitis: For instance, a specific Th17-like Treg subset can secrete IL-17 and express the chemokine receptor 6 (CCR6) and transcription factors, such as retinoic acid-related orphan receptor gamma t (RORγt), but possess the ability to repress the Th17 inflammatory response.20, 21, 22 In a T-cell transfer colitis model, CCR6−/− Tregs with impaired IL-10 production exhibited a defective suppressive function toward colitogenic inflammation in Rag2−/− C57BL/6 recipients, implying a critical role of CCR6 in Th17-like Treg function.