Our findings indicate that the onset of AAV-ILD is associated with a range of lifestyle, sociodemographic, and clinical factors, including age, male, smoking history, KL-6, ESR, MPO-ANCA, cough, dyspnea, and HRCT findings such as honeycombing, interlobular septal thickening, and lattice shadows, Ear, nose & throat involvement, Hb, alb, BVAS, and fever. This evidence concerns the gene GSTM1 and interstitial lung disease.