Elevated levels of sodium-hydrogen antiporter 3 regulator 1 (SLC9A3R1), B-lymphocyte surface antigen B1 (CD20), and growth factor receptor bound protein 2 (GRB2), along with reduced levels of cystatin-M (CST6), serpin family B member 5 (SERPINB5), and arginase-1 (ARG1), are found to be associated with regional lymph node metastasis in melanomas [34]. Here, SERPINB5 is linked to melanoma.