Naturallyoccurring rare germline variants of the CLCN2 gene have beenreported in human populations, as detailed in European epilepsy cohorts (36,37), a Central African cohort (38), and they are also associatedwith leukoencephalopathy and familial hyperaldosteronism type II (22,39). Here, CLCN2 is linked to Leukoencephalopathy.