Also, the study by Jiang et al.[51] (2018) evaluated 2,978patients and identified that preoperative NT-proBNP demonstrated an independent andsignificant association with postoperative severe heart failure (PSHF) in patientswith coronary artery disease (CAD) and mitral regurgitation (P <0.0001) and also with mitral stenosis (P = 0.047). The gene discussed is NPPB; the disease is mitral valve insufficiency.