rs1260326 and rs780094 have similar traits: increased risk of MASLD and progression to MASH with increased plasma triglycerides, LDL, VLDL, and 2 h plasma glucose in an oral glucose tolerance test (OGTT) and decreased FPG, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). This evidence concerns the gene INS and Insulin resistance.