Interestingly, in the cardiac ischemia-reperfusion model, RLN-2 was shown to reduce leukocyte density and inhibit the expression of cytokines, such as IL-1β, IL-6, and monocyte chemoattractant protein-1 (MCP-1), without affecting TNFα expression [60]. This evidence concerns the gene CCL2 and myocardial ischemia.