Several STS histotypes are characterized by the transcription of gene sets related to extracellular matrix and exhibit a spectrum of proteins involved in its remodeling.39,40 Sclerohyalinosis was associated with outcomes in patients with melanoma treated with neoadjuvant immune checkpoint inhibitors or BRAF/MEK-targeted therapies for locally advanced disease.41,42 The association between sclerohyalinosis and DFS observed in our study suggests possible mechanisms of extracellular matrix remodeling through chemotherapy-induced changes in the tumor cells and tumor microenvironment. This evidence concerns the gene BRAF and melanoma.