CDK4 and glomerular disorder: Several case reports for antibodies against EGFR report biopsy-proven glomerular disease.15,16,17,49,50,51,52 The effect of CDK4/6 inhibitors and BRAF inhibitors may be related to tubular injury based on limited biopsy reports.14 CDK4/6 inhibitors target regulators of cell cycle leading to cell cycle arrest.