TMEM97 and cancer: As a putative therapeutic target for cancer andAlzheimer’sdisease, the σ2R has attracted significant interestin the search for selective ligands. Severalligands have demonstrated promising efficacy in preclinical tumormodels, and σ2R selectivefluorescent probes have shown strong potential in cancer diagnostics. However, despite its pharmacological importance,the molecular mechanism of σ2R function remains poorlyunderstood.