The mutation frequencies of CRC typical driver genes, including APC, TP53, and KRAS, showed no obvious difference between paired T and LM samples (Figure 1C; Figure S1B, Supporting Information), which is similar to a prior report.[19] The significant amplifications shared by paired T and LM samples were on chromosomes 1q, 13q, 15q, and 17q, and deletions were on 1p, 10q, 12q, and 17q (FDR < 0.05). Here, APC is linked to colorectal carcinoma.