It exhibited inhibitory effects on various cellular signaling pathways, such as the oncogenic RAS, PI3K/AKT, and WNT pathways, highlighting its potential as a new therapeutic target in cancer treatment.[42] We uncovered a novel mechanism in which PIM kinase‐mediated phosphorylation of NDRG1 at Ser330 promoted its ubiquitination and subsequent degradation, thereby facilitating the liver metastasis of CRC. The gene discussed is NDRG1; the disease is colorectal carcinoma.