DIS3 and metastatic malignant neoplasm: Among them, DIS3, HNRNPA0, and PRPF8 were negatively correlated (FDR < 0.05) with the AS event of growth factor receptor‐bound protein 7 (GRB7), a gene reported to be overexpressed in invasive and metastatic cancer tissues.[51] Given that mRNA splicing can generate variants with different functions or shift the balance among isoforms, further biological investigation of the role of mRNA splicing isoforms in CRC metastasis is required.