There were no significant differences of the high‐frequence mutated genes (mutation frequency > 30%) between LM C1 and C2 subtypes, including the CRC driver genes APC, TP53, and KRAS (Figure 5A), while 17 low‐frequence mutated genes (mutation frequency ≤ 15%) showed significant difference (fisher exact test, p < 0.05), indicating small genomic difference between C1 and C2 subtypes. This evidence concerns the gene TP53 and colorectal carcinoma.